Chronic Pain Mechanism Research


  1. Pain Book 1st EditionLuo, Z.D. (Volume Editor) Pain Research: Methods and Protocols (2004). In: Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99. The Humana Press Inc., Totowa, NJ.

  2. Pain Research BookLuo, Z.D. (2nd Edition, Volume Editor) Pain Research: Methods and Protocols (2012). In: Methods in Molecular Medicine series. Ed. John M. Walker. Springer, New York, NY.

Book Chapters

  1. Taylor, P., Radic, Z., Kreienkamp, H-J., Luo, Z., Pickering, N. A. and Camp, S. Ligand specificity and gene expression in the cholinergic synapse: A comparison between acetylcholinesterase and the nicotinic acetylcholine receptor. (1995) In: Enzymes of the Cholinesterase Family. Eds. A. S. Balasubramanian, B. P. Doctor, P. Taylor and D. M. Quinn. Plenum Publishing Corporation, New York, New York
  2. Taylor, P., Luo, Z.D. and Camp, S. The genes encoding the cholinesterases: structure, evolutionary relationships and regulation of their expression (1999). In: Cholinesterases and Cholinesterase Inhibitors. Ed. Giacobini. Martin Dunitz Publishers, London.
  3. Luo, Z.D. Mechanistic dissection of pain: from DNA to animal models (2004) In: Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 1-10. The Humana Press Inc., Totowa, NJ.
  4. Higuera, E. S. and Luo, Z. D. A rat pain model of vincristine-induced neuropathy (2004). In Pain Research: Methods and Protocols (Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Vol. 99, pp 91-98. The Humana Press Inc., Totowa, NJ.
  5. Yaksh, T. L. and Luo, Z. D. Anatomy of the pain processing system (2006) In Pain Management Ed. S. D. Waldman. Elsevier, Philadelphia, PA.
  6. Yaksh, T. L. and Luo, Z. D. Anatomy of the pain processing system (2011) In Pain Management Ed. S. D. Waldman. 2nd Edition. Elsevier, Philadelphia, PA.
  7. Yaksh, T. L. and Luo, Z. D. Dynamics of the pain processing system (2011) In Pain Management Ed. S. D. Waldman. 2nd Edition. Elsevier, Philadelphia, PA.
  8. Luo, Z.D. Advancements in Pain Research (2012). In Pain Research: Methods and Protocols (2nd Edition, Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Springer, New York, NY.
  9. Sharp, K., Boroujerdi, A., Steward, O., and Luo, Z.D. A Rat Chronic Pain Model of Spinal Cord Contusion Injury (2012). In Pain Research: Methods and Protocols (2nd Edition, Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Springer, New York, NY.
  10. Perret, D., Kim, D-S., Li, K-W., and Luo, Z.D. Exposure of the Dorsal Root Ganglion to Pulsed Radiofrequency Current in a Neuropathic Pain Model of Peripheral Nerve Injury (2012). In Pain Research: Methods and Protocols (2nd Edition, Ed. ZD Luo). Methods in Molecular Medicine series. Ed. John M. Walker. Springer, New York, NY.
  11. Zhou, C. and Luo, Z.D. Sensory pathway modulation by calcium channel a2d1 subunit. (2013) In Modulation of presynaptic calcium channels. Eds. G. Stephens, S. Mochida. Springer, New York, NY.

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Journal Articles

  1. Luo, Z., Fuentes, M. E., and Taylor, P. Regulation of acetylcholinesterase mRNA stability by calcium during differentiation from myoblasts to myotubes. (1994) J. Biol. Chem. 269, 27216-27223
  2. Taylor, P., Radic, Z., Kreienkamp, H-J., Maeda, R. K., Luo, Z., Fuentes, M. E., Vellom, D. C., and Pickering, N. A. Expression and ligand specificity of acetylcholinesterase and the nicotinic receptors: a tale of two cholinergic sites. (1994) Biochem. Soc. Trans., 22, 740-745
  3. Luo, Z. D., Pincon-Raymond, M. and Taylor, P. Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel receptors. (1996) J. Neurochem. 67, 111-118
  4. Luo, Z. D., and Berman, H. A. The influence of Pb2+ on expression of acetylcholinesterase and the acetylcholine receptor. (1997) Toxicol. Appl. Pharmacol. 145, 237-245
  5. Okuse, K., Chaplan S. R., McMahon, S. B., Luo, Z. D., Calcutt, N. A., Scott, B. P., Akopian, A. N., and Wood, J. N. Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain (1997) Mol. Cell. Neurosci., 10, 196-207.
  6. Luo, Z. D., Camp, S., Mutero, A., and Taylor, P. Splicing of 5’ introns dictates alternative splice selection of acetylcholinesterase pre-mRNA and specific expression during myogenesis. (1998) J. Biol. Chem., 273, 28486-28495.
  7. Luo, Z. D., Wang, Y., G. Werlan, Camp, S., Chien, K. and Taylor, P. Calcineurin enhances mRNA stability of acetylcholinesterase during differentiation of C2-C12 muscle cells. (1999) Mol. Pharmacol., 56 (5), 886-894.
  8. Luo, Z. D., Chaplan, S. R., Scott, B. P., Cizkova, D., Calcutt, N. A. and Yaksh, T. L. Neuronal nitric oxide synthase mRNA up-regulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. (1999) J. Neurosci., 19 (21) 9201-9208.
  9. Luo, Z. D. Molecular dissection of pain mediators (2000). Pain Reviews. 7 (1), 37-64.
  10. Luo, Z.D. Rat dorsal root ganglia express distinctive forms of the α2 calcium channel subunit (2000) NeuroReport 11 (16), 3449-3452.
  11. Luo, Z.D. and Cizkova, D. The role of nitric oxide in nociception (2000) In: Current Review of Pain. Vol. 4 (6), 459-466. Eds. G.M. Aronoff, M.A. Giamberardino, O. de Leon-Casasola, R. P. Pawl, P. P. Rai, J. E. Heavner and H. Bosscher. Current Science Inc., Philadelphia.
  12. Luo, Z.D., Chaplan, S.R., Higuera, E.S., Sorkin, L.S., Stauderman, K.A., Williams, M.E., and Yaksh, T.L. Up-regulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve injured rats. (2001) J. Neurosci. 21(6), 1868-1875.
  13. Yaksh, T.L., Dirig, D.M., Conway, C.M., Svensson, C., Luo, Z.D. and Isakson, P.C. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2), but not COX-1. (2001) J. Neurosci. 21 (16), 5847-5853
  14. Luo, Z.D., Calcutt, N.A., Higuera, E.S., Valder, C.R., Svensson, C.I. and Myers, R.R. Injury type-specific calcium channel α2δ−1 subunit upregulation in rat neuropathic pain models correlates with anti-allodynic effects of gabapentin. (2002) J. Pharmacol. Exp. Ther. 303 (3), 1199-1205
  15. Schafers, M., Geis, C., Luo, Z.D., and Sommer, C. Selective increase of tumor necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve (2003) Eur. J. Neurosci. 17, 791-804.
  16. Valder, C.R., Liu, J-J., Song, Y-H., and Luo, Z.D. Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development. (2003) J. Neurochem. 87, 560-573.
  17. Luo, Z.D. and Berman, H.A. Pb++-mediated down-regulation of dihydropyridine receptors in skeletal muscle (2004) Toxic. Lett., 152, 167-173.
  18. Li, C-Y, Song, Y-H, Higuera, E. S., and Luo, Z.D. Spinal dorsal horn calcium channel alpha-2-delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. (2004) J. Neurosci. 24, 8818-8822.
  19. Li, C-Y, Zhang, X-L, Matthews, E. A., Li, K-W., Kurwa, A., Boroujerdi A, Gross J, Gold, M., Dickenson, A. H., Feng, G. and Luo, Z.D. Calcium Channel α2δ1 Subunit Mediates Spinal Hyperexcitability in Pain Modulation. (2006) Pain 125, 20-34.
  20. Hu, W-P., Zhang, C., Li, J-D., Luo, Z.D., Amadesi, S., Bunnett, N., and Zhou, Q-Y. Impaired pain sensation in mice lacking prokineticin 2. (2006) Mol. Pain, 2:35, 1-9
  21. Maneuf, Y.M., Luo, Z.D., and Lee, K. alpha-2-delta and mechanism of action of gabapentin in the treatment of pain. (2006) Semi. Cell Dev. Biol. 17:565-570.
  22. Xiao, W., Boroujerdi, A., Bennett, G.J., and Luo, Z.D. Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. (2007) Neuroscience, 144:714-720
  23. Luo, Z.D., Figueroa, K.W. Multiple genomic approach in pain research: basic science and clinical implications. (2008) Reviews in Analgesia 10:45-58
  24. Svensson, CI, Medicherla, S, Malkmus, S., Jiang, Y., Ma, JY, Kerr, I, Brainin-Mattos, J, Powell, HC, Luo, Z.D, Chakravarty, S, Dugar, S, Higgins, LS, Protter, AA, and Yaksh, TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. (2008) Pharmacology, Biochemistry and Behavior 90:664-675
  25. Boroujerdi, A., Kim, H-K., Lyu, Y-S., Kim, D-S., Figueroa, K.W., Chung, J.M., Luo, Z.D. Injury discharges induce calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to neuropathic pain initiation. (2008) Pain 139:358-366. PMID 18571852
  26. Nguyen, D., Deng, P., Matthews, E.A., Kim, D-S., Dickenson, A-H., Xu, Z.C., and Luo, Z.D. Enhanced pre-synaptic glutamate release in deep-dorsal horn regulates calcium channel alpha-2-dalta-1 protein-medicated spinal sensitization and behavioral hypersensitivity. (2009) Mol. Pain 5:6, 1-13 PMID 18571852
  27. Kim, D-S., Figueroa, K.W., Yolo, T., Boroujerdi, A., and Luo, Z.D. Characterization of dynamically changed gene expression during neuropathic pain development: injury-induced glial fibrillary acidic protein in dorsal root ganglia contributes to maintenance of neuropathic pain. (2009) Pain 143:114-122. PMID 19307059
  28. Perret, D. and Luo, Z.D. Targeting voltage-gated calcium channels for neuropathic pain management. (2009) Neurotherapeutics 6:679-692. PMID: 19789072
  29. Eroglu C, Allen N.J., Susman, M.W., O’Rourke, N.A., Park, C.Y., Ozkan, E., Charkraborty, C., Mulinyawe, S.B., Annis, D.S., Huberman A, Green, E.M., Lawler, J., Dolmetsch, R., Garcia, K.C., Smith, Luo Z.D., Rosenthal, A., Lawler, J., Mosher D.F., and Barres B.A. The calcium channel a2d1 is the neuronal thrombospondin receptor responsible for synaptogenesis. (2009) Cell 139:380-392. PMID: 19818485
  30. Lu, S-G., Zhang, X-L., Luo, Z.D., Gold, M.S. Persistent inflammation alters the density and distribution of voltage-activated calcium channel in subpopulations of rat cutaneous afferents. (2010) Pain 151:633-643. PMID: 20884119
  31. Park, J.F., and Luo, Z.D. Calcium Channel Functions in Pain Processing. (2010) Channels, 4:510-517. PMID: 21150297
  32. Boroujerdi, A, Zeng, J, Sharp, K, Kim, J, Steward, O, Luo, Z.D. Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury induced neuropathic pain states. (2011) Pain, 152:649-655. PMID: 21239111
  33. Perret, D.M., Kim, D-S., Sinavsky, K., Miller, J.M., Luo, Z.D. Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents modulates nerve injury-induced tactile allodynia. (2011) Anesthesia & Analgesia, 113:610-616. PMID: 21596869
  34. Kim, D-S., Li, K-W., Boroujerdi, A., Yu, Y. P., Zhou, C., Deng, P., Park, J., Zhang, X., Lee, J., Corpe, M., Sharp, K., Steward, O., Eroglu, C., Barres, B., Zaucke, F., Xu, Z.C., and Luo, Z.D. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain (2012) J. Neurosci., 32, 8977-8987. PMID: 22745497
  35. Chang, E. Y., Chen, X., Sandhu, A., Li, C-Y, Luo, Z. D. Spinal 5-HT3 receptors facilitate behavioral hypersensitivities induced by elevated calcium channel alpha-2-deltal-1 proteins. (2012) Eur. J. of Pain, 17, 505–513. PMID: 23065867
  36. Hata, J., Perret-Karimi, P., DeSilva, C., Leung, D., Betesh, N., Luo, Z.D., Dawodu, S., Sinavsky, K., Stokes, J., and English, S. Pulsed radiofrequency current in the treatment of pain. (2012) Critical Reviews in Physical and Rehabilitation Medicine, 23, 213-240
  37. Zeng, J., Kim, D., Li, K-W., Sharp, K., Steward, O., Zaucke, F., and Luo, Z. D. Thrombospondin-4 contributes to spinal cord injury induced changes in nociception. (2013) Eur. J. Pain, 17, 1458-1464. PMID: 23649982, PMCID: PMC3762950
  38. Li, K-W, Kim, D-S., Zaucke, F., and Luo, Z. D. Trigeminal nerve injury induced thrombospondin-4 upregulation contributes to orofacial neuropathic pain states in a rat model. (2013) Eur. J. Pain, 18, 489-495. PMID: 24019258, PMCID: PMC3947726
  39. Zhou, C., and Luo, Z. D. Electrophysiological characterization of dorsal horn neuron sensitization by elevated calcium channel alpha-2-delta-1 subunit protein. (2013) Eur. J. Pain, 18, 649-658. PMID: 24151064, PMCID: PMC3989413
  40. Zhang, Y., Wang, C., Wang, L., Parks, G.S., Zhang, X., Guo, Z., Ke, Y., Li, K-W., Kim, M.K., Vo, B., Borrelli, E., Yang, L., Ge, G., Yang, L., Wang, Z., Garcia-Fuster, M. J., Luo, Z. D., Liang, X., Civelli, O. A novel analgesic isolated from a traditional Chinese medicine. (2014) Current Biology, 24, 117-123. PMID: 24388848, PMCID: PMC3912990
  41. Chang, E., Zhao, X., Perret, D.M., Luo, Z. D., and Liao, S.S. A comprehensive, multi-specialty approach to an acute exacerbation of chronic central pain in a tetraplegic. (2014) Spinal Cord, 52 Suppl. 1:S17-18 PMID: 24513720
  42. Li, K-W, Yu, Y.P., Zhou, C., Kim, D-S, Lin, B., Sharp, K., Steward, O., and Luo, Z. D. Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. (2014) J. Biol. Chem., 289, 7025-7037. PMID: 24459143, PMCID: PMC3945363
  43. Chang, E.Y., Chen, X., Kim, M., Gong, N., Bhatia, S., and Luo, Z.D. Differential effects of voltage-gated calcium channel blockers on calcium channel alpha-2-delta-1 subunit protein mediated nociception. (2014) Eur. J. Pain, in press.

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